Protein profile

PA2151

alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase

Genome: NC_002516.2

Gene: PA2151 glgE Structure source: AlphaFold UniProt Q9I1W4
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Amino acids 664
Annotations 8
Features 18
PDB binders 1
Druggability 0.304

Overview

Basic information about this protein and its source genome.

Accession
PA2151
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2151 glgE
Status
annotated
Amino acids
664
Structure source
AlphaFold
EC
2.4.99.16
GO
GO:0004556 Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0030979 The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. GO:0009313 The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.304
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0004556 Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
  • GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
  • GO:0030979 The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.
  • GO:0009313 The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
21 202 Gene3D G3DSA:2.60.40.10 Immunoglobulins
21 202 InterPro IPR013783 Immunoglobulin-like fold
213 651 SMART SM00642 aamy
213 651 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
195 646 PANTHER PTHR47786 ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE
199 565 SUPERFAMILY SSF51445 (Trans)glycosidases
199 565 InterPro IPR017853 Glycoside hydrolase superfamily
21 203 Pfam PF11896 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S
21 203 InterPro IPR021828 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S
18 661 Hamap MF_02124 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [glgE].
18 661 InterPro IPR026585 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
205 567 Gene3D G3DSA:3.20.20.80 Glycosidases
570 664 Gene3D G3DSA:2.60.40.1180 -
570 664 InterPro IPR013780 Glycosyl hydrolase, all-beta
208 562 CDD cd11344 AmyAc_GlgE_like
108 184 Gene3D G3DSA:1.20.58.80 -
227 340 Pfam PF00128 Alpha amylase, catalytic domain
227 340 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2151
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.202

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

15 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ARE
3A6O
Q08751 807.7 Da LogP -10.74 TPSA 400.3 3 viol. ✓ Clean C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.