Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2155
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: clsB PA2155
Status: annotated
Amino acids: 401
Structure source: AlphaFold

EC

2.7.8.-

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

2.7.8.-

Gene Ontology (GO)

5

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.
GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
4	168	Gene3D	G3DSA:3.30.870.10	Endonuclease Chain A
3	175	SUPERFAMILY	SSF56024	Phospholipase D/nuclease
183	352	SUPERFAMILY	SSF56024	Phospholipase D/nuclease
254	352	Gene3D	G3DSA:3.30.870.10	Endonuclease Chain A
185	252	Gene3D	G3DSA:3.30.870.10	Endonuclease Chain A
190	331	CDD	cd09159	PLDc_ybhO_like_2
108	135	ProSiteProfiles	PS50035	Phospholipase D phosphodiesterase active site profile.
108	135	InterPro	IPR001736	Phospholipase D/Transphosphatidylase
278	305	ProSiteProfiles	PS50035	Phospholipase D phosphodiesterase active site profile.
278	305	InterPro	IPR001736	Phospholipase D/Transphosphatidylase
278	305	SMART	SM00155	pld_4
108	135	SMART	SM00155	pld_4
15	164	CDD	cd09110	PLDc_CLS_1
2	376	Hamap	MF_01917	Cardiolipin synthase B [clsB].
2	376	InterPro	IPR030872	Cardiolipin synthase B
4	364	PANTHER	PTHR21248	CARDIOLIPIN SYNTHASE
206	331	Pfam	PF13091	PLD-like domain
206	331	InterPro	IPR025202	Phospholipase D-like domain
24	138	Pfam	PF13091	PLD-like domain
24	138	InterPro	IPR025202	Phospholipase D-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2155	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.802

PA2155