Protein profile

PA2160

glycosyl hydrolase

Genome: NC_002516.2

Gene: PA2160 Structure source: AlphaFold UniProt Q9I1V5
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Amino acids 716
Annotations 5
Features 22
PDB binders 4
Druggability 0.542

Overview

Basic information about this protein and its source genome.

Accession
PA2160
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2160
Status
annotated
Amino acids
716
Structure source
AlphaFold
GO
GO:0004135 Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. GO:0005980 The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004133 OBSOLETE. Catalysis of the cleavage of branch points in branched glycogen polymers.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
27.179
Human E-value
1.39e-09
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.542
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0004135 Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.
  • GO:0005980 The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004133 OBSOLETE. Catalysis of the cleavage of branch points in branched glycogen polymers.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
19 107 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
19 107 InterPro IPR004193 Glycoside hydrolase, family 13, N-terminal
8 681 PANTHER PTHR43002 GLYCOGEN DEBRANCHING ENZYME
15 706 NCBIfam TIGR02100 glycogen debranching protein GlgX
15 706 InterPro IPR011837 Glycogen debranching enzyme, GlgX type
200 288 Pfam PF00128 Alpha amylase, catalytic domain
200 288 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
18 150 CDD cd02856 E_set_GDE_Isoamylase_N
18 150 InterPro IPR044505 Glycogen debranching enzyme GlgX/isoamylase, N-terminal Early set domain
149 587 SUPERFAMILY SSF51445 (Trans)glycosidases
149 587 InterPro IPR017853 Glycoside hydrolase superfamily
598 706 Gene3D G3DSA:2.60.40.1180 -
598 706 InterPro IPR013780 Glycosyl hydrolase, all-beta
153 581 CDD cd11326 AmyAc_Glg_debranch
598 706 SUPERFAMILY SSF51011 Glycosyl hydrolase domain
6 150 Gene3D G3DSA:2.60.40.10 Immunoglobulins
6 150 InterPro IPR013783 Immunoglobulin-like fold
15 158 SUPERFAMILY SSF81296 E set domains
15 158 InterPro IPR014756 Immunoglobulin E-set
190 578 SMART SM00642 aamy
190 578 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
151 588 Gene3D G3DSA:3.20.20.80 Glycosidases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2160
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.542
2 0.217

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ACG
1LWJ
P80099 791.8 Da LogP -9.71 TPSA 380.1 3 viol. ✓ Clean C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@…
BTB
3M07
Q8ZPF0 209.2 Da LogP -3.01 TPSA 104.4 ✓ Ro5 ✓ Clean C(CO)N(CCO)C(CO)(CO)CO
FLC
3VGB
Q55088 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
TAM
6JFJ
A0A0C5GWS2 163.2 Da LogP -1.17 TPSA 86.7 ✓ Ro5 ✓ Clean C(CO)C(CCO)(CCO)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.