Protein profile

PA2179

hypothetical protein

Genome: NC_002516.2

Gene: PA2179 Structure source: AlphaFold UniProt Q9I1T6
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Amino acids 316
Annotations 5
Features 10
PDB binders 6
Druggability 0.753

Overview

Basic information about this protein and its source genome.

Accession
PA2179
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2179
Status
annotated
Amino acids
316
Structure source
AlphaFold
GO
GO:0003676 Binding to a nucleic acid. GO:0036009 Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPSLNDPRLDVLVSLGNWLRGQDYRFVTVTPATHERVNARPENRMARDLAGIFGWSRAFAGESLPADWLTLLAGADLIRREADGWRSQVRVSSLGEQLFVHSAFPTLAADAVFFGPDTYRFDRLIRSHLASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAPGRFDLIVANPPYLLDASERAYRHGGGMLGAGLSLAIVDAALERLEAGGSLLLYTGVAMVEGGDPFLARIRERLASREWDWDYQELDPDVFAEELDSPAYREAERIAVVGLRVTRSA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003676 Binding to a nucleic acid.
  • GO:0036009 Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
129 252 Pfam PF05175 Methyltransferase small domain
129 252 InterPro IPR007848 Methyltransferase small domain
103 261 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
103 261 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
139 252 CDD cd02440 AdoMet_MTases
206 212 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature.
206 212 InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
62 259 PANTHER PTHR18895 HEMK METHYLTRANSFERASE
82 274 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
82 274 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2179
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.753

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
7QM
5U1I
Q2MG72 497.5 Da LogP -7.06 TPSA 274.4 2 viol. ✓ Clean CN[C@H]1[C@@H]([C@H](O[C@@H]([C@@H]1O)O[C@H]2[C…
7XP
5U0N
Q2MG72 454.5 Da LogP -6.65 TPSA 262.4 2 viol. ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C…
827
5U19
Q2MG72 482.5 Da LogP -6.00 TPSA 248.4 2 viol. ✓ Clean C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H…
9CS
5U1E
Q2MG72 483.5 Da LogP -7.33 TPSA 288.4 2 viol. ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C…
GET
5U18
Q2MG72 496.6 Da LogP -5.61 TPSA 248.4 2 viol. ✓ Clean C[C@H]([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@…
MEQ
1NV8
Q9WYV8 160.2 Da LogP -1.08 TPSA 92.4 ✓ Ro5 ✓ Clean CNC(=O)CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.