Protein profile

PA2193

hydrogen cyanide synthase subunit HcnA

Genome: NC_002516.2

Gene: hcnA PA2193 Structure source: AlphaFold UniProt G3XD67
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Amino acids 104
Annotations 6
Features 9
PDB binders 0
Druggability 0.594

Overview

Basic information about this protein and its source genome.

Accession
PA2193
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
hcnA PA2193
Status
annotated
Amino acids
104
Structure source
AlphaFold
EC
1.4.99.5
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0050622 Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. GO:0046872 Binding to a metal ion. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.594
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0050622 Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2.
  • GO:0046872 Binding to a metal ion.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
19 92 CDD cd00207 fer2
19 92 InterPro IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
18 100 SUPERFAMILY SSF54292 2Fe-2S ferredoxin-like
18 100 InterPro IPR036010 2Fe-2S ferredoxin-like superfamily
17 95 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain
3 101 Gene3D G3DSA:3.10.20.440 -
3 101 InterPro IPR042204 2Fe-2S iron-sulfur cluster binding domain, N-terminal
16 97 ProSiteProfiles PS51085 2Fe-2S ferredoxin-type iron-sulfur binding domain profile.
16 97 InterPro IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2193
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.594