Protein profile

PA2194

hydrogen cyanide synthase subunit HcnB

Genome: NC_002516.2

Gene: PA2194 hcnB Structure source: AlphaFold UniProt Q9I1S2
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Amino acids 464
Annotations 4
Features 20
PDB binders 0
Druggability 0.795

Overview

Basic information about this protein and its source genome.

Accession
PA2194
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2194 hcnB
Status
annotated
Amino acids
464
Structure source
AlphaFold
EC
1.4.99.5
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050622 Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.795
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0050622 Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
6 329 Gene3D G3DSA:3.50.50.60 -
6 329 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
369 439 Gene3D G3DSA:1.10.10.1100 -
369 439 InterPro IPR041854 BFD-like [2Fe-2S]-binding domain superfamily
6 330 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
6 330 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
380 433 CDD cd19946 GlpA-like_Fer2_BFD-like
107 125 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature
288 310 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature
257 273 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature
5 24 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature
1 464 PIRSF PIRSF037495 OoxA/HcnB
1 464 InterPro IPR017224 Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B
120 264 Gene3D G3DSA:3.50.50.60 -
120 264 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
381 424 Pfam PF04324 BFD-like [2Fe-2S] binding domain
381 424 InterPro IPR007419 BFD-like [2Fe-2S]-binding domain
2 438 PANTHER PTHR42949 ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT B
6 311 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase
6 311 InterPro IPR023753 FAD/NAD(P)-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2194
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.795
14 0.231