Protein profile

PA2196

transcriptional regulator

Genome: NC_002516.2

Gene: PA2196 Structure source: Experimental + AlphaFold UniProt Q9I1S1
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Amino acids 194
Annotations 4
Features 17
PDB binders 0
Druggability 0.907

Overview

Basic information about this protein and its source genome.

Accession
PA2196
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2196
Status
annotated
Amino acids
194
Structure source
Experimental + AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.907
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
2 73 SUPERFAMILY SSF46689 Homeodomain-like
2 73 InterPro IPR009057 Homeobox-like domain superfamily
33 56 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
33 56 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 25 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
12 25 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 54 Pfam PF00440 Bacterial regulatory proteins, tetR family
12 54 InterPro IPR001647 DNA-binding HTH domain, TetR-type
6 66 ProSiteProfiles PS50977 TetR-type HTH domain profile.
6 66 InterPro IPR001647 DNA-binding HTH domain, TetR-type
104 187 Pfam PF16925 Tetracyclin repressor-like, C-terminal domain
104 187 InterPro IPR011075 Tetracyclin repressor-like, C-terminal domain
1 190 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
1 194 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
81 192 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
81 192 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
4 193 FunFam G3DSA:1.10.357.10:FF:000058 Probable transcriptional regulator

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3RD3
X-ray 2.40 Å A,B
100.0% 1-194
PDBe RCSB PDBj File
Viewing
PDB 4L62
X-ray 2.90 Å A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P
97.9% 4-193
PDBe RCSB PDBj File
Loaded
AlphaFold PA2196
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.907
2 0.298

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.92 0.704
2 1.17 0.01