Protein profile

PA2206

transcriptional regulator

Genome: NC_002516.2

Gene: PA2206 Structure source: AlphaFold UniProt Q9I1R1
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Amino acids 315
Annotations 5
Features 14
PDB binders 6
Druggability 0.789

Overview

Basic information about this protein and its source genome.

Accession
PA2206
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2206
Status
annotated
Amino acids
315
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:1901031 Any process that modulates the frequency, rate or extent of response to reactive oxygen species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.789
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1901031 Any process that modulates the frequency, rate or extent of response to reactive oxygen species.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
13 123 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
13 123 InterPro IPR036390 Winged helix DNA-binding domain superfamily
14 71 ProSiteProfiles PS50931 LysR-type HTH domain profile.
14 71 InterPro IPR000847 Transcription regulator HTH, LysR
14 100 FunFam G3DSA:1.10.10.10:FF:000628 LysR family transcriptional regulator
104 312 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
14 312 PANTHER PTHR30126 HTH-TYPE TRANSCRIPTIONAL REGULATOR
16 75 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
16 75 InterPro IPR000847 Transcription regulator HTH, LysR
14 100 Gene3D G3DSA:1.10.10.10 -
14 100 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
106 312 Gene3D G3DSA:3.40.190.290 -
102 307 Pfam PF03466 LysR substrate binding domain
102 307 InterPro IPR005119 LysR, substrate-binding

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2206
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.789
6 0.667

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BEZ
2F7A
O68014 122.1 Da LogP 1.38 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(=O)O
MLI
4IHS
O68014 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
PEO
4X6G
Q9HTL4 34.0 Da LogP 0.02 TPSA 40.5 ✓ Ro5 ✓ Clean OO
RUB
5Z49
Q9F1R2 310.1 Da LogP -2.50 TPSA 191.0 1 viol. ✓ Clean C([C@H]([C@H](C(=O)COP(=O)(O)O)O)O)OP(=O)(O)O
SKM
5TED
Q8Y9N7 174.2 Da LogP -1.52 TPSA 98.0 ✓ Ro5 ✓ Clean C1[C@H]([C@@H]([C@@H](C=C1C(=O)O)O)O)O
TSU
3FXU
P94678 172.2 Da LogP 1.24 TPSA 54.4 ✓ Ro5 ✓ Clean Cc1ccc(cc1)S(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.