Protein profile

PA2218

hypothetical protein

Genome: NC_002516.2

Gene: PA2218 Structure source: Experimental + AlphaFold UniProt Q01609
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Amino acids 367
Annotations 1
Features 20
PDB binders 0
Druggability 0.935

Overview

Basic information about this protein and its source genome.

Accession
PA2218
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2218
Status
annotated
Amino acids
367
Structure source
Experimental + AlphaFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.935
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
48 367 PANTHER PTHR47751 SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED
206 296 Gene3D G3DSA:1.10.10.800 -
19 31 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
32 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
78 216 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family)
78 216 InterPro IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain
1 31 SignalP_EUK SignalP-noTM SignalP-noTM
69 363 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
69 363 InterPro IPR029058 Alpha/Beta hydrolase fold
1 39 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 39 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
1 31 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
206 296 FunFam G3DSA:1.10.10.800:FF:000002 OpdE downstream ORF 2, putative
1 36 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
37 367 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45 367 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
45 367 InterPro IPR029058 Alpha/Beta hydrolase fold
1 36 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2HDW
X-ray 2.00 Å A,B
98.9% 5-367
PDBe RCSB PDBj File
Viewing
AlphaFold PA2218
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.935
1 0.886

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.87 0.893
2 1.56 0.024
3 1.45 0.019
4 1.38 0.017
5 0.72 0.002