Protein profile

PA2221

hypothetical protein

Genome: NC_002516.2

Gene: PA2221 Structure source: AlphaFold UniProt Q9I1P8

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Amino acids 401

Annotations 2

Features 12

PDB binders 0

Druggability 0.63

Overview

Basic information about this protein and its source genome.

Accession: PA2221
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2221
Status: annotated
Amino acids: 401
Structure source: AlphaFold

GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.63

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTAATCGWVTMSMRELDRLKVIEAIIEGRLKPAAAAQRLRLTTRQVHRLVLRYREDGPAGLTSRRRGQPSNRQLSPGLENPAISLIRRNYSDFGPTLAQEKLVECHGLKLAKETVRRIMVDAGMWVPRKQRPPKVYQPRNRRACCGELIQIDDGKPLAFYSDKASVFRSNHKAPQGGDGYTQFGRAMYELNIESCANSSQAKGRVERANLTLQDRLVKELRLRGISNMADANAFAAHFMASYNARFAKPPRSEHDCHRPLHSDEDLELIFAWREARRVSQRLTVQYDKVLYLLADTPQSRRLAGDHVDDLPLPEWPHRAQGGRHRPPLYHLRQTLRDRPGCHRREQALGSCAASRPARPSAARQSALAIGTGKSAAVNARQDAVEEGAARTDAGRYRRCPG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0003676 Binding to a nucleic acid.
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
18	79	Pfam	PF13551	Winged helix-turn helix
141	254	Gene3D	G3DSA:3.30.420.10	-
141	254	InterPro	IPR036397	Ribonuclease H superfamily
5	123	SUPERFAMILY	SSF46689	Homeodomain-like
5	123	InterPro	IPR009057	Homeobox-like domain superfamily
154	247	SUPERFAMILY	SSF53098	Ribonuclease H-like
154	247	InterPro	IPR012337	Ribonuclease H-like superfamily
64	78	MobiDBLite	mobidb-lite	consensus disorder prediction
147	267	ProSiteProfiles	PS50994	Integrase catalytic domain profile.
147	267	InterPro	IPR001584	Integrase, catalytic core
58	78	MobiDBLite	mobidb-lite	consensus disorder prediction
10	154	PANTHER	PTHR35004	TRANSPOSASE RV3428C-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2221	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.63