Protein profile

PA2223

hypothetical protein

Genome: NC_002516.2

Gene: PA2223 Structure source: AlphaFold UniProt Q9I1P6

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Amino acids 339

Annotations 3

Features 8

PDB binders 0

Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession: PA2223
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2223
Status: annotated
Amino acids: 339
Structure source: AlphaFold

GO:0003796 Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. GO:0042742 Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. GO:0031640 Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0003796 Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.
GO:0042742 Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
GO:0031640 Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
169	299	Pfam	PF16754	Bacterial toxin homologue of phage lysozyme, C-term
169	299	InterPro	IPR031922	Pesticin, C-terminal
154	336	SUPERFAMILY	SSF53955	Lysozyme-like
154	336	InterPro	IPR023346	Lysozyme-like domain superfamily
154	338	Gene3D	G3DSA:1.10.530.40	-
154	338	InterPro	IPR023347	Lysozyme domain superfamily
151	333	CDD	cd16902	pesticin_lyz
151	333	InterPro	IPR031922	Pesticin, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2223	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.813