Protein profile

PA2237

biofilm formation protein PslG

Genome: NC_002516.2

Gene: PA2237 pslG Structure source: Experimental + AlphaFold UniProt Q9I1N2
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Amino acids 442
Annotations 3
Features 13
PDB binders 0
Druggability 0.785

Overview

Basic information about this protein and its source genome.

Accession
PA2237
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2237 pslG
Status
annotated
Amino acids
442
Structure source
Experimental + AlphaFold
GO
GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. GO:0071704 OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.785
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MARKGLYLGGSALLLAVVLLLVFWGRPADAEIQVLKAPRAVVWKDFLGVNAQFLWFSPERYNKQIDRLQDLGLEWVRLDLHWDRLETAEDQYQLASLDQLVKDLEARQLKSVFYLVGSARFITTAPFYSPFQDQYPPRDPEVFARRMAMLSQRYPSVAAWQVWNEPNLIGFWRPKADPEGYAKLLQASTIALRMVDPEKPVVSAGMAFFSEMPDGRTMFDALGHLGVESLGTIATYHPYTQLPEGNYPWNLDFVSHANQINRALRNAGVPAIWSTEWGWSAYKGPKELQDIIGVEGQADYVLRRLALMSALDYDRIFLFTLSDLDQRASVRDRDYGLLDLDANPKPVYLALQRFLKVTGPKLRPADPPVTEDLPDGSFSIGWTREDGRNVWLFWSARGGNVRLPKLKEATLHDPLSGKVTPLSGSDGLEVPVKSSLQMLVWE

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
  • GO:0071704 OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
6 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 30 SignalP_EUK SignalP-TM SignalP-TM
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 285 Pfam PF00150 Cellulase (glycosyl hydrolase family 5)
48 285 InterPro IPR001547 Glycoside hydrolase, family 5
31 442 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
41 356 Gene3D G3DSA:3.20.20.80 Glycosidases
13 401 PANTHER PTHR12631 ALPHA-L-IDURONIDASE
43 358 SUPERFAMILY SSF51445 (Trans)glycosidases
43 358 InterPro IPR017853 Glycoside hydrolase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9G18
X-ray 1.50 Å A
93.2% 31-442
PDBe RCSB PDBj File
Viewing
PDB 9G17
X-ray 1.55 Å A
93.2% 31-442
PDBe RCSB PDBj File
Loaded
PDB 5BXA
X-ray 1.90 Å A
93.2% 31-442
PDBe RCSB PDBj File
Loaded
PDB 4ZN2
X-ray 2.00 Å A,B,C,D
93.2% 31-442
PDBe RCSB PDBj File
Loaded
PDB 5BX9
X-ray 2.00 Å A
93.2% 31-442
PDBe RCSB PDBj File
Loaded
AlphaFold PA2237
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.785
1 0.674

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 35.55 0.953
2 9.29 0.498
3 3.35 0.119
4 2.27 0.057
5 1.52 0.022