Protein profile

PA2239

biofilm formation protein PslI

Genome: NC_002516.2

Gene: PA2239 pslI Structure source: AlphaFold UniProt Q9I1N0
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Amino acids 367
Annotations 3
Features 8
PDB binders 0
Druggability 0.373

Overview

Basic information about this protein and its source genome.

Accession
PA2239
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2239 pslI
Status
annotated
Amino acids
367
Structure source
AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.373
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
10 365 PANTHER PTHR46401 GLYCOSYLTRANSFERASE WBBK-RELATED
1 190 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
196 350 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
2 361 CDD cd03809 GT4_MtfB-like
13 366 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
17 183 Pfam PF13439 Glycosyltransferase Family 4
17 183 InterPro IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain
203 309 Pfam PF13692 Glycosyl transferases group 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2239
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.373
4 0.239