Protein profile

PA2252

AGCS sodium/alanine/glycine symporter

Genome: NC_002516.2

Gene: PA2252 Structure source: AlphaFold UniProt Q9I1L7
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Amino acids 481
Annotations 5
Features 50
PDB binders 0
Druggability 0.941

Overview

Basic information about this protein and its source genome.

Accession
PA2252
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2252
Status
annotated
Amino acids
481
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.941
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
90 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 27 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
134 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
174 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
85 89 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203 222 PRINTS PR00175 Sodium/alanine symporter signature
203 222 InterPro IPR001463 Sodium:alanine symporter
400 420 PRINTS PR00175 Sodium/alanine symporter signature
400 420 InterPro IPR001463 Sodium:alanine symporter
84 106 PRINTS PR00175 Sodium/alanine symporter signature
84 106 InterPro IPR001463 Sodium:alanine symporter
294 312 PRINTS PR00175 Sodium/alanine symporter signature
294 312 InterPro IPR001463 Sodium:alanine symporter
340 362 PRINTS PR00175 Sodium/alanine symporter signature
340 362 InterPro IPR001463 Sodium:alanine symporter
175 193 PRINTS PR00175 Sodium/alanine symporter signature
175 193 InterPro IPR001463 Sodium:alanine symporter
155 173 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114 133 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
65 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
374 393 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
178 200 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
455 481 MobiDBLite mobidb-lite consensus disorder prediction
28 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
84 99 ProSitePatterns PS00873 Sodium:alanine symporter family signature.
84 99 InterPro IPR001463 Sodium:alanine symporter
50 444 Pfam PF01235 Sodium:alanine symporter family
50 444 InterPro IPR001463 Sodium:alanine symporter
72 94 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 444 FunFam G3DSA:1.20.1740.10:FF:000004 Sodium:alanine symporter family protein
2 448 PANTHER PTHR30330 AGSS FAMILY TRANSPORTER, SODIUM-ALANINE
2 448 InterPro IPR001463 Sodium:alanine symporter
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
363 373 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
316 340 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 442 Gene3D G3DSA:1.20.1740.10 Amino acid/polyamine transporter I
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
422 481 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
291 313 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
291 315 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
398 421 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
339 361 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
374 392 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
403 425 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
195 290 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
341 362 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 431 NCBIfam TIGR00835 amino acid carrier protein
13 431 InterPro IPR001463 Sodium:alanine symporter
393 397 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2252
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.941
10 0.403
8 0.271
2 0.201