Protein profile

PA2255

paerucumarin biosynthesis protein PvcB

Genome: NC_002516.2

Gene: pvcB PA2255 Structure source: Experimental + AlphaFold UniProt Q9I1L4
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Amino acids 291
Annotations 4
Features 7
PDB binders 0
Druggability 0.407

Overview

Basic information about this protein and its source genome.

Accession
PA2255
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pvcB PA2255
Status
annotated
Amino acids
291
Structure source
Experimental + AlphaFold
EC
1.14.20.9
GO
GO:0016706 Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872 Binding to a metal ion. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.407
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0016706 Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
  • GO:0046872 Binding to a metal ion.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
14 280 CDD cd00250 CAS_like
1 291 Gene3D G3DSA:3.60.130.10 -
1 291 InterPro IPR042098 Taurine dioxygenase TauD-like superfamily
22 277 SUPERFAMILY SSF51197 Clavaminate synthase-like
45 274 PANTHER PTHR10696 GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED
43 275 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family
43 275 InterPro IPR003819 TauD/TfdA-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4YLM
X-ray 2.05 Å X
100.0% 1-291
PDBe RCSB PDBj File
Viewing
PDB 3EAT
X-ray 2.50 Å X
100.0% 1-291
PDBe RCSB PDBj File
Loaded
AlphaFold PA2255
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.407
2 0.397

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.93 0.534
2 3.17 0.108
3 1.99 0.042
4 1.49 0.021