Protein profile

PA2269

hypothetical protein

Genome: NC_002516.2

Gene: PA2269 Structure source: AlphaFold UniProt Q9I1K4
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Amino acids 401
Annotations 2
Features 45
PDB binders 0
Druggability 0.857

Overview

Basic information about this protein and its source genome.

Accession
PA2269
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2269
Status
annotated
Amino acids
401
Structure source
AlphaFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.857
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

45 records
Show feature table
Start End DB Term Name
273 295 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
46 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
209 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
105 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
360 364 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
213 401 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
213 401 InterPro IPR020846 Major facilitator superfamily domain
190 208 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
46 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
325 335 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
232 245 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
167 189 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
387 401 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
246 267 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 400 PANTHER PTHR23542 -
79 98 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
297 301 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
302 324 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
301 323 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
336 359 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
171 189 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
147 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 45 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
209 231 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 78 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
127 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
336 358 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
79 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
368 390 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 229 Pfam PF07690 Major Facilitator Superfamily
20 229 InterPro IPR011701 Major facilitator superfamily
268 278 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
279 296 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 106 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 389 SUPERFAMILY SSF103473 MFS general substrate transporter
17 389 InterPro IPR036259 MFS transporter superfamily
20 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
246 268 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
107 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
365 386 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
209 391 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
209 391 InterPro IPR036259 MFS transporter superfamily
16 194 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
16 194 InterPro IPR036259 MFS transporter superfamily
166 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2269
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.857
3 0.537