Protein profile

PA2271

acetyltransferase

Genome: NC_002516.2

Gene: PA2271 Structure source: Experimental + AlphaFold UniProt Q9I1K2
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Amino acids 171
Annotations 2
Features 9
PDB binders 0
Druggability 0.769

Overview

Basic information about this protein and its source genome.

Accession
PA2271
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2271
Status
annotated
Amino acids
171
Structure source
Experimental + AlphaFold
EC
2.3.1.-
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.769
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 152 Gene3D G3DSA:3.40.630.30 -
56 118 CDD cd04301 NAT_SF
3 162 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
3 162 InterPro IPR000182 GNAT domain
53 136 Pfam PF13508 Acetyltransferase (GNAT) domain
53 136 InterPro IPR000182 GNAT domain
1 138 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 138 InterPro IPR016181 Acyl-CoA N-acyltransferase
3 144 PANTHER PTHR43800 PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9CR5
X-ray 1.56 Å A,B
100.0% 1-171
PDBe RCSB PDBj File
Viewing
AlphaFold PA2271
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.769

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 36.88 0.956
2 1.39 0.017