Protein profile

PA2279

low molecular weight phosphatase

Genome: NC_002516.2

Gene: PA2279 GNQ48_26180 PAERUG_P19_London_7_VIM_2_05_10_04700 IPC1295_16570 GUL26_31370 arsC CAZ10_28375 DT376_17880 ALP65_03876 arsC_4 Structure source: AlphaFold UniProt O68022 UniProt G3XD22

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Amino acids 156

Annotations 1

Features 10

PDB binders 2

Overview

Basic information about this protein and its source genome.

Accession: PA2279
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2279 GNQ48_26180 PAERUG_P19_London_7_VIM_2_05_10_04700 IPC1295_16570 GUL26_31370 arsC CAZ10_28375 DT376_17880 ALP65_03876 arsC_4
Status: annotated
Amino acids: 156
Structure source: AlphaFold

GO:0046685 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0046685 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
2	135	CDD	cd16345	LMWP_ArsC
1	19	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	136	SMART	SM00226	LMWPc_2
1	136	InterPro	IPR023485	Phosphotyrosine protein phosphatase I
3	134	Pfam	PF01451	Low molecular weight phosphotyrosine protein phosphatase
3	134	InterPro	IPR023485	Phosphotyrosine protein phosphatase I
1	136	SUPERFAMILY	SSF52788	Phosphotyrosine protein phosphatases I
1	136	InterPro	IPR036196	Phosphotyrosine protein phosphatase I superfamily
2	144	PANTHER	PTHR43428	ARSENATE REDUCTASE
1	135	Gene3D	G3DSA:3.40.50.2300	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA2279 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2279	AlphaFold	—	—	full sequence	—	Viewing

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
LCP	1JFV	P0A006	99.4 Da LogP -4.76 TPSA 92.2	✓ Ro5	✓ Clean	`[O-]Cl(=O)(=O)=O`
MNB	1RXE	P0A006	199.2 Da LogP 1.58 TPSA 80.4	✓ Ro5	✓ Clean	`c1cc(c(cc1S)C(=O)O)[N+](=O)[O-]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Ligand	UniProt (homolog)	pchembl	MW · LogP · TPSA	Lipinski	PAINS	SMILES
CHEMBL4448703	P0A006	—	305.3 Da LogP 3.52 TPSA 51.6	✓ Ro5	Alert	`CC(C)n1c2ccccc2c2ccc3c(c21)C(=O)C1OC1C3=O`

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC2575270	0.656	211.1 Da LogP 0.99 TPSA 117.7	✓ Ro5	✓ Clean	`O=C(O)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC4404106	0.656	212.1 Da LogP 1.20 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1cc([N+](=O)[O-])ccc1[N+](=O)[O-]`
ZINC2565533	0.655	256.1 Da LogP 0.90 TPSA 160.9	✓ Ro5	✓ Clean	`O=C(O)c1cc(C(=O)O)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC1689765	0.636	201.6 Da LogP 1.95 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(Cl)ccc1[N+](=O)[O-]`
ZINC1692553	0.636	246.0 Da LogP 2.06 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(Br)ccc1[N+](=O)[O-]`
ZINC34143793	0.636	293.0 Da LogP 1.90 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(I)ccc1[N+](=O)[O-]`
ZINC19801481	0.600	223.2 Da LogP 2.59 TPSA 80.4	✓ Ro5	✓ Clean	`CC(C)(C)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC1870293	0.583	247.1 Da LogP 0.10 TPSA 138.0	✓ Ro5	✓ Clean	`O=C(O)c1cc(P(=O)(O)O)ccc1[N+](=O)[O-]`
ZINC197020550	0.583	246.2 Da LogP -0.06 TPSA 140.6	✓ Ro5	✓ Clean	`NS(=O)(=O)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC19845324	0.583	210.2 Da LogP 1.36 TPSA 83.7	✓ Ro5	✓ Clean	`CN(C)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC59269089	0.583	245.2 Da LogP 0.70 TPSA 114.6	✓ Ro5	✓ Clean	`CS(=O)(=O)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC72338575	0.583	235.1 Da LogP 2.31 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(C(F)(F)F)ccc1[N+](=O)[O-]`
ZINC7814925	0.583	213.2 Da LogP 2.01 TPSA 80.4	✓ Ro5	✓ Clean	`CSc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC3845121	0.576	226.1 Da LogP 0.57 TPSA 143.8	✓ Ro5	✓ Clean	`Nc1cc([N+](=O)[O-])c(C(=O)O)cc1C(=O)O`
ZINC4284655	0.568	224.2 Da LogP 1.25 TPSA 109.5	✓ Ro5	✓ Clean	`CC(=O)Nc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC346060	0.559	245.6 Da LogP 1.64 TPSA 117.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(C(=O)O)c([N+](=O)[O-])cc1Cl`
ZINC14985550	0.553	225.2 Da LogP 1.08 TPSA 106.7	✓ Ro5	✓ Clean	`COC(=O)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC15443713	0.553	236.2 Da LogP 1.89 TPSA 83.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(N2CCCC2)ccc1[N+](=O)[O-]`
ZINC1610707	0.553	269.3 Da LogP 3.46 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(/C=C/c2ccccc2)ccc1[N+](=O)[O-]`
ZINC19400583	0.553	225.2 Da LogP 2.08 TPSA 89.7	✓ Ro5	✓ Clean	`CC(C)Oc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC22163863	0.553	259.2 Da LogP 3.09 TPSA 89.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(Oc2ccccc2)ccc1[N+](=O)[O-]`
ZINC5160214	0.553	269.3 Da LogP 3.46 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(/C=C\c2ccccc2)ccc1[N+](=O)[O-]`
ZINC238666021	0.545	234.1 Da LogP 2.65 TPSA 43.1	✓ Ro5	✓ Clean	`O=[N+]([O-])c1ccc(S)cc1Br`
ZINC16698051	0.543	293.0 Da LogP 1.90 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1ccc(I)cc1[N+](=O)[O-]`
ZINC39263556	0.543	217.2 Da LogP 2.45 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc2ccccc2cc1[N+](=O)[O-]`
ZINC13179356	0.538	250.3 Da LogP 2.28 TPSA 83.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(N2CCCCC2)ccc1[N+](=O)[O-]`
ZINC16158718	0.538	251.1 Da LogP 2.19 TPSA 89.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(OC(F)(F)F)ccc1[N+](=O)[O-]`
ZINC16385345	0.538	208.1 Da LogP 2.23 TPSA 129.2	✓ Ro5	Alert	`[N-]=[N+]=Nc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC19735959	0.538	264.3 Da LogP 2.67 TPSA 83.7	✓ Ro5	✓ Clean	`O=C(O)c1cc(N2CCCCCC2)ccc1[N+](=O)[O-]`
ZINC19844564	0.538	238.2 Da LogP 2.14 TPSA 83.7	✓ Ro5	✓ Clean	`CCN(CC)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC22214518	0.538	211.2 Da LogP 1.69 TPSA 89.7	✓ Ro5	✓ Clean	`CCOc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC2569918	0.529	203.1 Da LogP 1.57 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(F)c(F)cc1[N+](=O)[O-]`
ZINC32169655	0.529	236.0 Da LogP 2.60 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(Cl)c(Cl)cc1[N+](=O)[O-]`
ZINC4529802	0.529	324.9 Da LogP 2.82 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(Br)c(Br)cc1[N+](=O)[O-]`
ZINC13275004	0.525	309.7 Da LogP 4.10 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1cc(Sc2ccc(Cl)cc2)ccc1[N+](=O)[O-]`
ZINC13179470	0.524	252.3 Da LogP 2.53 TPSA 83.7	✓ Ro5	✓ Clean	`CCCCN(C)c1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC5248656	0.516	256.1 Da LogP 0.90 TPSA 160.9	✓ Ro5	✓ Clean	`O=C(O)c1c([N+](=O)[O-])ccc([N+](=O)[O-])c1C(=O)O`
ZINC95347800	0.515	233.1 Da LogP 2.44 TPSA 37.3	✓ Ro5	✓ Clean	`O=C(O)c1cc(S)ccc1Br`
ZINC147083096	0.514	245.6 Da LogP 1.64 TPSA 117.7	✓ Ro5	✓ Clean	`O=C(O)c1cc([N+](=O)[O-])c(C(=O)O)cc1Cl`
ZINC1571172	0.514	290.0 Da LogP 1.75 TPSA 117.7	✓ Ro5	✓ Clean	`O=C(O)c1cc([N+](=O)[O-])c(C(=O)O)cc1Br`
ZINC16384168	0.514	228.1 Da LogP 0.91 TPSA 143.8	✓ Ro5	✓ Clean	`O=C(O)c1ccc([N+](=O)[O-])c(O)c1[N+](=O)[O-]`
ZINC1715466	0.514	225.2 Da LogP 1.30 TPSA 117.7	✓ Ro5	✓ Clean	`Cc1cc(C(=O)O)c([N+](=O)[O-])cc1C(=O)O`
ZINC1764711	0.514	212.1 Da LogP 1.20 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC2147511	0.514	291.0 Da LogP 1.96 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1cc(Br)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC2172990	0.514	246.6 Da LogP 1.85 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1cc(Cl)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC2540295	0.514	230.1 Da LogP 1.34 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1cc(F)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC3115866	0.514	226.1 Da LogP 1.51 TPSA 123.6	✓ Ro5	✓ Clean	`Cc1cc(C(=O)O)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC3115867	0.514	338.0 Da LogP 1.81 TPSA 123.6	✓ Ro5	✓ Clean	`O=C(O)c1cc(I)c([N+](=O)[O-])cc1[N+](=O)[O-]`
ZINC85314	0.514	211.1 Da LogP 0.99 TPSA 117.7	✓ Ro5	✓ Clean	`O=C(O)c1ccc(C(=O)O)c([N+](=O)[O-])c1`
ZINC96028572	0.514	203.1 Da LogP 1.57 TPSA 80.4	✓ Ro5	✓ Clean	`O=C(O)c1ccc([N+](=O)[O-])c(F)c1F`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.