Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2280
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2280
Status: annotated
Amino acids: 230
Structure source: AlphaFold

GO

GO:0052873 Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.768

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0052873 Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+.
GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
20	216	NCBIfam	TIGR02690	arsenical resistance protein ArsH
20	216	InterPro	IPR014063	Arsenate resistance ArsH
1	230	Gene3D	G3DSA:3.40.50.360	-
1	230	InterPro	IPR029039	Flavoprotein-like superfamily
21	217	SUPERFAMILY	SSF52218	Flavoproteins
21	217	InterPro	IPR029039	Flavoprotein-like superfamily
208	228	Coils	Coil	Coil
1	230	FunFam	G3DSA:3.40.50.360:FF:000027	Arsenical resistance protein ArsH
24	166	Pfam	PF03358	NADPH-dependent FMN reductase
24	166	InterPro	IPR005025	NADPH-dependent FMN reductase-like
18	228	PANTHER	PTHR43590	ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)
18	228	InterPro	IPR014063	Arsenate resistance ArsH

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2280	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.7
2				0.453

PA2280