Protein profile

PA2301

hypothetical protein

Genome: NC_002516.2

Gene: PA2301 Structure source: AlphaFold UniProt Q9I1H4
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Amino acids 180
Annotations 2
Features 8
PDB binders 0
Druggability 0.754

Overview

Basic information about this protein and its source genome.

Accession
PA2301
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2301
Status
annotated
Amino acids
180
Structure source
AlphaFold
GO
GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA. GO:0106074 Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.754
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MVLREYTQRHRLDAVAPADYHRHLPEQVARGLPSAELVVFRVADEHSDTAAFSARYGFGLEDCANTLVLRYKRDGAEGYAAVVNLGSRRLDVNGAVKALLGARRLSFAAREVATELTGMQFGGITAFGLPEGMPLLVDAAVFERPLVVMGAGVRETKLLLSPALLKDLPGVVVAELSEAG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0002161 The hydrolysis of an incorrectly aminoacylated tRNA.
  • GO:0106074 Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
36 174 CDD cd04939 PA2301
34 178 Gene3D G3DSA:3.90.960.10 -
34 178 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily
48 167 Pfam PF04073 Aminoacyl-tRNA editing domain
48 167 InterPro IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain
41 175 PANTHER PTHR30411 UNCHARACTERIZED
35 176 SUPERFAMILY SSF55826 YbaK/ProRS associated domain
35 176 InterPro IPR036754 YbaK/aminoacyl-tRNA synthetase-associated domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2301
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.754