Protein profile

PA2314

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA2314 Structure source: AlphaFold UniProt Q9I1G1
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Amino acids 417
Annotations 3
Features 47
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
PA2314
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2314
Status
annotated
Amino acids
417
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

47 records
Show feature table
Start End DB Term Name
116 138 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
257 279 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 116 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
173 177 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
259 279 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
60 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
335 345 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
202 221 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
225 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 258 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
375 397 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
280 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 391 SUPERFAMILY SSF103473 MFS general substrate transporter
17 391 InterPro IPR036259 MFS transporter superfamily
178 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
81 91 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
368 378 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
176 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
349 371 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
92 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 338 Pfam PF07690 Major Facilitator Superfamily
31 338 InterPro IPR011701 Major facilitator superfamily
150 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
399 417 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
26 396 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
26 396 InterPro IPR020846 Major facilitator superfamily domain
222 244 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
379 398 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
346 367 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 393 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
24 393 InterPro IPR036259 MFS transporter superfamily
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
315 334 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
307 329 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
41 59 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
139 149 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 83 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
286 309 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
310 314 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 391 CDD cd17324 MFS_NepI_like
286 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 393 PANTHER PTHR43124 PURINE EFFLUX PUMP PBUE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2314
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.87
12 0.25