Protein profile

PA2321

gluconokinase

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_04988 PA2321 GUL26_29725 gntK CAZ10_35955 gnuK Structure source: AlphaFold UniProt Q9ZIJ2 UniProt G3XD53
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Amino acids 173
Annotations 6
Features 17
PDB binders 0
Druggability 0.625

Overview

Basic information about this protein and its source genome.

Accession
PA2321
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_04988 PA2321 GUL26_29725 gntK CAZ10_35955 gnuK
Status
annotated
Amino acids
173
Structure source
AlphaFold
EC
2.7.1.12
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046316 Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+. GO:0019521 The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
48.0
Human E-value
1.71e-08
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.625
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046316 Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.
  • GO:0019521 The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
8 152 CDD cd02021 GntK
8 152 InterPro IPR006001 Carbohydrate kinase, thermoresistant glucokinase
5 170 Gene3D G3DSA:3.40.50.300 -
5 170 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 157 PANTHER PTHR43442 GLUCONOKINASE-RELATED
7 157 InterPro IPR006001 Carbohydrate kinase, thermoresistant glucokinase
7 167 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
7 167 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
9 139 Pfam PF13671 AAA domain
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
8 168 NCBIfam TIGR01313 gluconokinase, GntK/IdnK-type
8 168 InterPro IPR006001 Carbohydrate kinase, thermoresistant glucokinase
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
3 170 FunFam G3DSA:3.40.50.300:FF:000522 Gluconokinase
25 173 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2321
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.229