Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2328
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2328
Status: annotated
Amino acids: 399
Structure source: AlphaFold

GO

GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0009970 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GO:0009970 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
285	359	SUPERFAMILY	SSF53213	LigB-like
42	276	SUPERFAMILY	SSF53850	Periplasmic binding protein-like II
16	29	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	15	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
17	378	PANTHER	PTHR30024	ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
43	263	CDD	cd13553	PBP2_NrtA_CpmA_like
43	263	InterPro	IPR044527	Nitrate/bicarbonate ABC transporter substrate-binding domain
1	36	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	36	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
145	375	Gene3D	G3DSA:3.40.190.10	-
40	129	Gene3D	G3DSA:3.40.190.10	-
1	38	ProSiteProfiles	PS51318	Twin arginine translocation (Tat) signal profile.
1	38	InterPro	IPR006311	Twin-arginine translocation pathway, signal sequence
38	279	Pfam	PF13379	NMT1-like family
37	399	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30	36	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2328	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.511
2				0.299

PA2328