Protein profile

PA2345

hypothetical protein

Genome: NC_002516.2

Gene: PA2345 Structure source: AlphaFold UniProt Q9I1D3
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Amino acids 411
Annotations 5
Features 17
PDB binders 1
Druggability 0.829

Overview

Basic information about this protein and its source genome.

Accession
PA2345
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2345
Status
annotated
Amino acids
411
Structure source
AlphaFold
GO
GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0070224 Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone. GO:0070221 A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
38.608
Human E-value
4.4399999999999997e-39
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.829
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
  • GO:0070224 Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone.
  • GO:0070221 A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 12 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 152 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
11 152 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
125 266 Gene3D G3DSA:3.50.50.60 -
125 266 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
13 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 411 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 133 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase
12 133 InterPro IPR023753 FAD/NAD(P)-binding domain
123 266 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
123 266 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
125 266 FunFam G3DSA:3.50.50.60:FF:000034 sulfide:quinone oxidoreductase, mitochondrial
7 403 PANTHER PTHR10632 SULFIDE:QUINONE OXIDOREDUCTASE
7 403 InterPro IPR015904 Sulphide quinone-reductase
13 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 330 Gene3D G3DSA:3.50.50.60 -
13 330 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2345
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.829

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

74 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
UQ1
6OIB
Q9Y6N5 250.3 Da LogP 2.32 TPSA 52.6 ✓ Ro5 Alert CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)C

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.