Protein profile

PA2357

FMN reductase MsuE

Genome: NC_002516.2

Gene: msuE slfA PA2357 Structure source: AlphaFold UniProt O31038
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Amino acids 186
Annotations 4
Features 8
PDB binders 0
Druggability 0.687

Overview

Basic information about this protein and its source genome.

Accession
PA2357
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
msuE slfA PA2357
Status
annotated
Amino acids
186
Structure source
AlphaFold
EC
1.5.1.38
GO
GO:0052873 Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.687
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTSPFKVVAVSGGTYRPSRTLVLTQALIAELGQSLPIDSRVIELTDIAAPLGATLARNQAPAELQAVLDEIESADLLLVASPVYRGSYPGLLKHLFDLIDLNALIDTPVLLAATGGTERHALVLDHQLRPLFSFFQAITLPIGVYASEADFDNYRIVSEPLKARIRLAAERAAPLFGGRSELLKIA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0052873 Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+.
  • GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
6 150 Pfam PF03358 NADPH-dependent FMN reductase
6 150 InterPro IPR005025 NADPH-dependent FMN reductase-like
5 182 PANTHER PTHR43408 FMN REDUCTASE (NADPH)
1 176 SUPERFAMILY SSF52218 Flavoproteins
1 176 InterPro IPR029039 Flavoprotein-like superfamily
6 177 NCBIfam TIGR03566 FMN reductase
6 177 InterPro IPR019912 FMN reductase, MsuE-like
1 176 Gene3D G3DSA:3.40.50.360 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2357
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.687
1 0.443
2 0.392