Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2389
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: pvdR PA2389
Status: annotated
Amino acids: 391
Structure source: AlphaFold

GO

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0019898 The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GO:1990195 A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MRRTRSTRRALLVAVCLSPLIALAAWQAYPFRSNNFDTVSVSRGSIESSVSALGTLQPRRYVDVGAQASGQIRKLHVEAGDDVTEGQLLVEIDPSTQQAKVDAGRYSIEMLKAQLAEQRAQYTLARQQYQRQQRLAAGGATRTEDVQSAQAQMLATQARIEMYQAQIRQAQASLRSDEAELGYTRIYAPMSGTVVAVDAREGQTLNAQQQTPLILRIAKLSPMTVWAQVSEADIGRVKPGMPAYFTTLSGEGRRWTGKVRQILPVPPKPLDQSNQGGGSPTSGSGGQSGSGRVVLYTVLVDVDNGDHQLMAEMTAQVFFVAATAENILTAPVAAIHDDGKGGQVAWVVGSNGKPQSRQIRTGISDRLRVQVLAGLEEGDRLLMAAPDGSDS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0019898 The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GO:1990195 A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
GO:1990961 A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
261	287	MobiDBLite	mobidb-lite	consensus disorder prediction
319	385	Gene3D	G3DSA:2.40.420.20	-
108	135	Coils	Coil	Coil
95	182	Gene3D	G3DSA:6.10.140.1990	-
95	182	InterPro	IPR030190	Macrolide export protein MacA, alpha-hairpin domain superfamily
47	265	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
47	265	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
38	264	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
38	264	InterPro	IPR006143	RND efflux pump, membrane fusion protein
25	391	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
272	287	MobiDBLite	mobidb-lite	consensus disorder prediction
1	24	Phobius	SIGNAL_PEPTIDE	Signal peptide region
4	388	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
51	252	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
10	20	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	28	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	24	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
61	217	Gene3D	G3DSA:2.40.50.100	-
218	318	Gene3D	G3DSA:2.40.30.170	-
146	180	Coils	Coil	Coil
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
21	24	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
12	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2389	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.753
4				0.607
3				0.374

PA2389