Protein profile

PA2392

pyoverdine biosynthesis protein PvdP

Genome: NC_002516.2

Gene: PA2392 pvdP Structure source: Experimental + AlphaFold UniProt Q9I188
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Amino acids 544
Annotations 3
Features 10
PDB binders 0
Druggability 0.892

Overview

Basic information about this protein and its source genome.

Accession
PA2392
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2392 pvdP
Status
annotated
Amino acids
544
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion. GO:0004503 Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.892
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0046872 Binding to a metal ion.
  • GO:0004503 Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.
  • GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
535 544 Coils Coil Coil
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
251 444 SUPERFAMILY SSF48056 Di-copper centre-containing domain
251 444 InterPro IPR008922 Di-copper centre-containing domain superfamily
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
3 21 NCBIfam TIGR01409 twin-arginine translocation signal domain
3 21 InterPro IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
20 544 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6RRR
X-ray 2.11 Å A,B
100.0% 1-544
PDBe RCSB PDBj File
Viewing
PDB 6RRP
X-ray 2.40 Å A,B
100.0% 1-544
PDBe RCSB PDBj File
Loaded
PDB 6RRQ
X-ray 2.70 Å A,B
100.0% 1-544
PDBe RCSB PDBj File
Loaded
AlphaFold PA2392
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.545
2 0.466

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.71 0.622
2 10.28 0.552
3 2.62 0.076
4 2.46 0.067
5 2.23 0.054