Protein profile

PA2407

adhesion protein

Genome: NC_002516.2

Gene: PA2407 Structure source: Experimental + AlphaFold UniProt Q9I174
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Amino acids 317
Annotations 4
Features 34
PDB binders 1
Druggability 0.808

Overview

Basic information about this protein and its source genome.

Accession
PA2407
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2407
Status
annotated
Amino acids
317
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0006829 The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.808
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0046872 Binding to a metal ion.
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0006829 The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
195 313 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
1 37 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
21 32 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
41 313 SUPERFAMILY SSF53807 Helical backbone metal receptor
33 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
67 85 PRINTS PR00691 Adhesin B signature
67 85 InterPro IPR006129 Adhesin B
86 105 PRINTS PR00691 Adhesin B signature
86 105 InterPro IPR006129 Adhesin B
144 163 PRINTS PR00691 Adhesin B signature
144 163 InterPro IPR006129 Adhesin B
202 219 PRINTS PR00691 Adhesin B signature
202 219 InterPro IPR006129 Adhesin B
42 63 PRINTS PR00691 Adhesin B signature
42 63 InterPro IPR006129 Adhesin B
255 273 PRINTS PR00690 Adhesin family signature
255 273 InterPro IPR006128 Adhesion lipoprotein
202 223 PRINTS PR00690 Adhesin family signature
202 223 InterPro IPR006128 Adhesion lipoprotein
73 86 PRINTS PR00690 Adhesin family signature
73 86 InterPro IPR006128 Adhesion lipoprotein
86 103 PRINTS PR00690 Adhesin family signature
86 103 InterPro IPR006128 Adhesion lipoprotein
40 313 CDD cd01017 AdcA
41 194 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
1 37 SignalP_EUK SignalP-noTM SignalP-noTM
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 310 Pfam PF01297 Zinc-uptake complex component A periplasmic
48 310 InterPro IPR006127 Periplasmic solute binding protein, ZnuA-like
174 194 Coils Coil Coil
38 317 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 314 PANTHER PTHR42953 HIGH-AFFINITY ZINC UPTAKE SYSTEM PROTEIN ZNUA-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6R3Z
X-ray 1.65 Å A
88.3% 38-317
PDBe RCSB PDBj File
Viewing
PDB 6R44
X-ray 1.99 Å A,B
88.3% 38-317
PDBe RCSB PDBj File
Loaded
PDB 6R6K
X-ray 2.10 Å A,B
88.3% 38-317
PDBe RCSB PDBj File
Loaded
PDB 6RU4
X-ray 2.49 Å A,B,C,D
88.3% 38-317
PDBe RCSB PDBj File
Loaded
PDB 6R5S
X-ray 2.75 Å A,B
88.3% 38-317
PDBe RCSB PDBj File
Loaded
AlphaFold PA2407
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.557

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.0 0.16
2 3.0 0.098

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CAC
3UJP
Q79EF9 137.0 Da LogP -0.52 TPSA 40.1 ✓ Ro5 ✓ Clean C[As](=O)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.