Protein profile

PA2412

hypothetical protein

Genome: NC_002516.2

Gene: PA2412 Structure source: Experimental + AlphaFold UniProt Q9I169
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Amino acids 72
Annotations 3
Features 10
PDB binders 4
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
PA2412
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2412
Status
annotated
Amino acids
72
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. GO:0019290 The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
  • GO:0019290 The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 69 PANTHER PTHR38444 ENTEROBACTIN BIOSYNTHESIS PROTEIN YBDZ
1 69 InterPro IPR037407 MbtH-like protein
1 72 Gene3D G3DSA:3.90.820.10 -
3 53 SMART SM00923 MbtH_2
3 53 InterPro IPR005153 MbtH-like domain
1 72 FunFam G3DSA:3.90.820.10:FF:000003 Antibiotic synthesis protein MbtH
1 53 Pfam PF03621 MbtH-like protein
1 53 InterPro IPR005153 MbtH-like domain
1 69 SUPERFAMILY SSF160582 MbtH-like
1 69 InterPro IPR038020 MbtH-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2PST
X-ray 1.80 Å X
100.0% 1-72
PDBe RCSB PDBj File
Viewing
PDB 5JA2
X-ray 3.00 Å B
100.0% 1-72
PDBe RCSB PDBj File
Loaded
AlphaFold PA2412
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

26 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
75C
5JA2 3.00 Å Open crystal
773.8 Da LogP -4.51 TPSA 356.9 3 viol. ✓ Clean CC(C)(COP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCS[C@@H]…
BU9
5JA2 3.00 Å Open crystal
90.1 Da LogP -0.25 TPSA 40.5 ✓ Ro5 ✓ Clean C[C@H]([C@H](C)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.