Protein profile

PA2428

hypothetical protein

Genome: NC_002516.2

Gene: PA2428 Structure source: AlphaFold UniProt Q9I154
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Amino acids 304
Annotations 5
Features 11
PDB binders 8
Druggability 0.579

Overview

Basic information about this protein and its source genome.

Accession
PA2428
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2428
Status
annotated
Amino acids
304
Structure source
AlphaFold
EC
2.7.4.-
GO
GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0006754 The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006183 The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. GO:0006793 The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.579
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).
  • GO:0006754 The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0006183 The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.
  • GO:0006793 The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
49 274 NCBIfam TIGR03707 polyphosphate kinase 2
49 274 InterPro IPR022486 Polyphosphate kinase 2, PA0141
49 274 Pfam PF03976 Polyphosphate kinase 2 (PPK2)
49 274 InterPro IPR022488 Polyphosphate kinase-2-related
14 288 Gene3D G3DSA:3.40.50.300 -
14 288 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
21 293 PANTHER PTHR34383 POLYPHOSPHATE:AMP PHOSPHOTRANSFERASE-RELATED
12 304 PIRSF PIRSF028756 PPK2
12 304 InterPro IPR016898 Polyphosphate phosphotransferase
80 268 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
80 268 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2428
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.579
1 0.489

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

15 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
6YW
5LLF
Q5NEQ5 497.9 Da LogP -0.34 TPSA 310.4 2 viol. ✓ Clean OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP…
6YX
5LLF
Q5NEQ5 1937.5 Da LogP 1.76 TPSA 1148.0 3 viol. ✓ Clean OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP…
6YY
5LLF
Q5NEQ5 897.8 Da LogP 0.24 TPSA 543.1 3 viol. ✓ Clean OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP…
DPO
5O6K
M9XB82 173.9 Da LogP -3.34 TPSA 135.6 ✓ Ro5 ✓ Clean [O-]P(=O)([O-])OP(=O)([O-])[O-]
FLC
3RHF
A1R8G0 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
MLI
3CZP
Q9HYF1 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
MLT
6DZG
Q92SA6 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
PPV
5MAQ
M9XB82 178.0 Da LogP -0.81 TPSA 124.3 ✓ Ro5 ✓ Clean OP(=O)(O)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.