Protein profile

PA2430

hypothetical protein

Genome: NC_002516.2

Gene: PA2430 Structure source: AlphaFold UniProt Q9I152

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Amino acids 334

Annotations 2

Features 14

PDB binders 0

Druggability 0.946

Overview

Basic information about this protein and its source genome.

Accession: PA2430
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2430
Status: annotated
Amino acids: 334
Structure source: AlphaFold

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.946

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
1	27	Phobius	SIGNAL_PEPTIDE	Signal peptide region
11	23	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
45	260	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
45	260	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
45	233	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
1	10	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
104	124	Coils	Coil	Coil
198	322	Gene3D	G3DSA:2.40.30.170	-
28	334	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	324	PANTHER	PTHR30367	P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
45	133	Gene3D	G3DSA:2.40.50.100	-
159	186	Coils	Coil	Coil
24	27	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
10	28	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2430	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.946
1				0.358