Protein profile

PA2431

hypothetical protein

Genome: NC_002516.2

Gene: PA2431 Structure source: AlphaFold UniProt Q9I151
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Amino acids 724
Annotations 3
Features 38
PDB binders 0
Druggability 0.709

Overview

Basic information about this protein and its source genome.

Accession
PA2431
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2431
Status
annotated
Amino acids
724
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.709
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MEGLKFYARLLWRPPRETLLFALRTVAAGLLTLYLAFLFDLEQPKWALMTVVIVSQPLAGMALKRSFAQVLGTFAGAVVAVLIMALFAQQPLPFFVALGLWLALCTAGGTLLRYTDSHAFVLSGFTAVIVAVLSIPDPENTFMLAVVRVTETLLGVACVALVSLLSARPQAVAKGYFAQVDGLIRSTARHAAAVIRGDEGDESFNQRQMQLVASITALDGLRRHLYFDAPNLRRADGLVQLLGNLLVLMASRLLLLRQHRLLVRAHWVGPLPADIQALLDRALRVLDALAEQGRAVPSEVLEEFQAVRQAFDAAATRAESYDEALSPALRPQVAILRWEYARLFQRLGEVLELNDAIQSGRQASSFYRRGQAQALHLDWALASMNAVRAFVALSCAAWLWITSAWNGALSSLLLVGVMCSLMATFPRPLLAAQNFLRGLLLAILISAALLFVLLPASADFEWLALWMALLLYVVAVGLSSPLSAGIAMGIGLETLLMVAPQNIAVYYSNASQWFEFVGGFLAAAVLAVLVFALVYPFRADPRLRRLLYLSRQDVAEMSRCEASEAQRFAFETRMIDRLAVMVGLLPASQEPASAERFQCALGCVVMGVALNRLREPLHDAGVVPLELQPLLGEALREVAAYIAGGADAPRQDLALAALRRFGRGLEALLAQPSKDLGATRQRFIMNVAVLILQQSLQRYRTLLEEDRGAPAVVEEPEEEGGHAR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
462 479 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
402 406 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
433 455 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
64 69 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
45 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
396 418 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
513 535 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
407 426 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
379 401 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
480 485 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
94 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
427 437 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
70 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
462 479 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
137 141 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 592 PANTHER PTHR30509 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED
536 724 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
113 118 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
486 507 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 698 Pfam PF04632 Fusaric acid resistance protein family
19 698 InterPro IPR006726 Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein
89 93 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
438 456 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
484 506 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
119 136 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
513 535 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
457 461 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
508 512 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
142 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
166 378 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2431
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.408
2 0.385
1 0.261