Protein profile

PA2438

hypothetical protein

Genome: NC_002516.2

Gene: PA2438 Structure source: AlphaFold UniProt Q9I144
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Amino acids 341
Annotations 3
Features 18
PDB binders 0
Druggability 0.844

Overview

Basic information about this protein and its source genome.

Accession
PA2438
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2438
Status
annotated
Amino acids
341
Structure source
AlphaFold
GO
GO:0098797 Any protein complex that is part of the plasma membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547 Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.844
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0098797 Any protein complex that is part of the plasma membrane.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0052547 Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
55 240 Pfam PF01145 SPFH domain / Band 7 family
55 240 InterPro IPR001107 Band 7 domain
85 227 Gene3D G3DSA:3.30.479.30 Band 7 domain
85 227 InterPro IPR036013 Band 7/SPFH domain superfamily
87 230 SUPERFAMILY SSF117892 Band 7/SPFH domain
87 230 InterPro IPR036013 Band 7/SPFH domain superfamily
28 333 PIRSF PIRSF005651 HflC
28 333 InterPro IPR010200 HflC
37 56 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 59 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 312 CDD cd03405 SPFH_HflC
52 312 InterPro IPR010200 HflC
57 341 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
51 225 SMART SM00244 PHB_4
51 225 InterPro IPR001107 Band 7 domain
1 27 MobiDBLite mobidb-lite consensus disorder prediction
35 327 PANTHER PTHR42911 MODULATOR OF FTSH PROTEASE HFLC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2438
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.473
6 0.262