Protein profile

PA2439

hypothetical protein

Genome: NC_002516.2

Gene: PA2439 Structure source: AlphaFold UniProt Q9I143
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Amino acids 666
Annotations 1
Features 35
PDB binders 0
Druggability 0.918

Overview

Basic information about this protein and its source genome.

Accession
PA2439
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2439
Status
annotated
Amino acids
666
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.918
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
226 236 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
157 167 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
171 190 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
137 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 205 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 313 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
55 60 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 136 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
237 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
318 621 CDD cd03404 SPFH_HflK
318 621 InterPro IPR010201 HflK
314 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 336 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
334 552 Pfam PF01145 SPFH domain / Band 7 family
334 552 InterPro IPR001107 Band 7 domain
644 666 MobiDBLite mobidb-lite consensus disorder prediction
1 30 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
168 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
420 537 Gene3D G3DSA:3.30.479.30 Band 7 domain
420 537 InterPro IPR036013 Band 7/SPFH domain superfamily
329 647 PANTHER PTHR43327 STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL
642 666 MobiDBLite mobidb-lite consensus disorder prediction
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
61 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
431 540 SUPERFAMILY SSF117892 Band 7/SPFH domain
431 540 InterPro IPR036013 Band 7/SPFH domain superfamily
333 666 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
206 225 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
203 225 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
235 257 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
330 535 SMART SM00244 PHB_4
330 535 InterPro IPR001107 Band 7 domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2439
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.856
3 0.837
2 0.396