Protein profile
PA2446
glycine cleavage system protein H
Genome: NC_002516.2
Overview
Basic information about this protein and its source genome.
- Accession
- PA2446
- Gene
- gcvH2
- Status
- annotated
- Amino acids
- 127
- Structure source
- Unavailable
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 49.451
- Human E-value
- 1.72e-22
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Unknown
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
2- GO:0005960 A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
- GO:0019464 The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 2 | 122 | SUPERFAMILY | SSF51230 | Single hybrid motif |
| 2 | 122 | InterPro | IPR011053 | Single hybrid motif |
| 20 | 101 | ProSiteProfiles | PS50968 | Biotinyl/lipoyl domain profile. |
| 20 | 101 | InterPro | IPR000089 | Biotin/lipoyl attachment |
| 2 | 122 | PANTHER | PTHR11715 | GLYCINE CLEAVAGE SYSTEM H PROTEIN |
| 2 | 122 | InterPro | IPR002930 | Glycine cleavage system H-protein |
| 6 | 100 | CDD | cd06848 | GCS_H |
| 6 | 100 | InterPro | IPR033753 | Glycine cleavage system H-protein/Simiate |
| 1 | 121 | Gene3D | G3DSA:2.40.50.100 | - |
| 4 | 122 | Pfam | PF01597 | Glycine cleavage H-protein |
| 4 | 122 | InterPro | IPR033753 | Glycine cleavage system H-protein/Simiate |
| 1 | 122 | Hamap | MF_00272 | Glycine cleavage system H protein [gcvH]. |
| 1 | 122 | InterPro | IPR002930 | Glycine cleavage system H-protein |
| 3 | 123 | NCBIfam | TIGR00527 | glycine cleavage system protein GcvH |
| 3 | 123 | InterPro | IPR017453 | Glycine cleavage system H-protein, subgroup |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| LPB | P16048 | 206.3 Da LogP 2.79 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
C1CSS[C@H]1CCCCC(=O)O
|
|
| OSS | P16048 | 313.5 Da LogP 2.41 TPSA 83.5 | ✓ Ro5 | ✓ Clean |
C(CCC(=O)O)C[C@@H](CCSCN)SSCCO
|
|
| RED | P16048 | 208.3 Da LogP 2.25 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
C(CCC(=O)O)C[C@H](CCS)S
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC1529363 | 1.000 | 208.3 Da LogP 2.25 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCC[C@H](S)CCS
|
| ZINC3869601 | 1.000 | 208.3 Da LogP 2.25 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCC[C@@H](S)CCS
|
| ZINC12954423 | 0.538 | 232.4 Da LogP 3.90 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCS
|
| ZINC2164257 | 0.538 | 218.4 Da LogP 3.51 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCS
|
| ZINC90745150 | 0.538 | 260.4 Da LogP 4.68 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCCCS
|
| ZINC2151107 | 0.500 | 231.3 Da LogP 1.60 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
NC(CCCCC(=O)O)CCCCC(=O)O
|
| ZINC2839271 | 0.500 | 245.3 Da LogP 1.99 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC(=O)O)CCCCC(=O)O
|
| ZINC2839272 | 0.500 | 245.3 Da LogP 1.99 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCC(=O)O)CCCCC(=O)O
|
| ZINC44713478 | 0.500 | 260.4 Da LogP 3.06 TPSA 77.8 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCCCC(O)O
|
| ZINC4783630 | 0.500 | 346.5 Da LogP 3.34 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCC[C@H](O)[C@H](O)CCCCCCCC(=O)O
|
| ZINC4783631 | 0.500 | 346.5 Da LogP 3.34 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCC[C@@H](O)[C@H](O)CCCCCCCC(=O)O
|
| ZINC4783632 | 0.500 | 346.5 Da LogP 3.34 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCC[C@H](O)[C@@H](O)CCCCCCCC(=O)O
|
| ZINC4956318 | 0.500 | 273.4 Da LogP 2.77 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCCCC(=O)O)CCCCC(=O)O
|
| ZINC4956319 | 0.500 | 273.4 Da LogP 2.77 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCCCC(=O)O)CCCCC(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.
3D Structure
No structural model is available for this protein.
Structure unavailable
No pre-computed model was found in the AlphaFold database and no ColabFold prediction is available for this protein.