Protein profile

PA2448

hypothetical protein

Genome: NC_002516.2

Gene: PA2448 Structure source: AlphaFold UniProt Q9I134
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Amino acids 580
Annotations 1
Features 20
PDB binders 0
Druggability 0.692

Overview

Basic information about this protein and its source genome.

Accession
PA2448
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2448
Status
annotated
Amino acids
580
Structure source
AlphaFold
GO
GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.692
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MKQRIPTLLAGACLAIPLHALGAADLLVVNARIFTANPQQPFAEALAVEDGRILAVGDEAGLRALADGDSQVVDLGGKRLMPGLIDTHSHAVFGGLELAGADMGNEQVGLDELERRLRAWRDNGKARHGDMLNVSGMHTAYWSQVKDFRARFDHGEWADQPLAFIGSDHHTGWANAAMLKRAGIDAARVRALPEEQRNTIGHDADATPNGFLADAGLDAVLAVLPAPSAEQMLEAGRSAVRYSNSLGLTAWMDPAANGSPGDALFSLRPDENTVGVLPVYHRLAKGGELSAHVAALLVANPRSRPTDLEVLDKVRQRFLGSPNLTLPGIKVFADGVPEYPAQTAALLEPYRNSRKTGELLIDPAHFGELVSAADARGWLVHVHAIGDRAVREALNGMQQARRDRDSGIAHSITHLQLVNPKEFERFRPLGVIASMQLYWAAADETTVDLMKPYISAFAYRYQYPAHSLLSKGATIAGASDWPVSSLSPWKAIQQAVTRKGPQGVLNAGERLDRQTMFYAYTRNAARTIGLEHRIGSLEPGKQADFIVLDRDVFEVPETQLGETKVLKTWFAGKPVYSSEG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
82 536 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
82 536 InterPro IPR032466 Metal-dependent hydrolase
101 227 Gene3D G3DSA:3.10.310.70 -
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
83 535 Gene3D G3DSA:3.20.20.140 -
20 579 PANTHER PTHR22642 IMIDAZOLONEPROPIONASE
45 547 CDD cd01300 YtcJ_like
45 547 InterPro IPR033932 YtcJ like
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 577 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
22 577 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
24 580 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
71 576 Pfam PF07969 Amidohydrolase family
71 576 InterPro IPR013108 Amidohydrolase 3
29 552 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
29 552 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2448
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.692