Protein profile

PA2465

hypothetical protein

Genome: NC_002516.2

Gene: PA2465 Structure source: Experimental + AlphaFold UniProt Q9I117
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Amino acids 382
Annotations 1
Features 17
PDB binders 0
Druggability 0.941

Overview

Basic information about this protein and its source genome.

Accession
PA2465
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2465
Status
annotated
Amino acids
382
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.941
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
349 371 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
145 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 380 PANTHER PTHR34219 IRON-REGULATED INNER MEMBRANE PROTEIN-RELATED
1 380 InterPro IPR005625 PepSY-associated TM protein
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
170 201 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
350 371 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
202 221 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
8 373 Pfam PF03929 PepSY-associated TM region
8 373 InterPro IPR005625 PepSY-associated TM protein
372 382 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
222 349 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7ABW
X-ray 3.35 Å A,B
100.0% 1-382
PDBe RCSB PDBj File
Viewing
AlphaFold PA2465
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.941
1 0.264

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 43.12 0.969
2 32.76 0.944
3 18.13 0.815
4 17.3 0.8
5 5.38 0.255