Protein profile

PA2467

anti-sigma factor FoxR

Genome: NC_002516.2

Gene: PA2467 foxR Structure source: AlphaFold UniProt Q9I115
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Amino acids 328
Annotations 2
Features 13
PDB binders 0
Druggability 0.755

Overview

Basic information about this protein and its source genome.

Accession
PA2467
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2467 foxR
Status
annotated
Amino acids
328
Structure source
AlphaFold
GO
GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.755
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDGTRGRVDEAVVRQAIHWLVRLRSQPADDRLQRACAAWRAEHGEHERAWQQVSALNEELQGRFKALPGGVAYGTLDSSAQRLQRRQALKLLSLLVAGGAVAWVGRDSLPWQRLSADYSTATGERRSIELVDGTRLQLNTDSAVDVRYDAGQRLILLARGEIFLASGADTQSPTHRPLRVRTAQGLFEALGTRFNVRLQDAATCLSVSEGSVRIDAFGARPLQAPVAEAGQSYRIAADGVRRLERPQMDAVAWADGLIVTRDMRLADFLAEVARYRNGYLGCAAEVADLRLSGVYRLDDTDKLLQVLARTLPVRLQRHTRWWVRVVAA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
  • GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
14 56 Pfam PF16220 Domain of unknown function (DUF4880)
14 56 InterPro IPR032623 FecR, N-terminal
10 325 PANTHER PTHR30273 PERIPLASMIC SIGNAL SENSOR AND SIGMA FACTOR ACTIVATOR FECR-RELATED
10 325 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component
88 105 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
106 328 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
105 247 FunFam G3DSA:2.60.120.1440:FF:000002 Probable transmembrane sensor
1 87 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
106 249 Gene3D G3DSA:2.60.120.1440 -
4 328 PIRSF PIRSF018266 FecR
4 328 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component
117 213 Pfam PF04773 FecR protein
117 213 InterPro IPR006860 FecR protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2467
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.755