Overview
Basic information about this protein and its source genome.
- Accession
- PA2470
- Gene
- gtdA PA2470
- Status
- annotated
- Amino acids
- 353
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
MHNDNSTEKRADFYRRIRQQHLTPLWEALHSLVPAQPAGGCQAALWRYRELRPFLLEAGDLISAEEAVRRVLVLENPDLPGQSSITPSLYAGLQLILPGEIAPSHRHTQSALRFVVEGYGAYTSVDGERTRMEPGDFIITPSWTWHDHGNRAAAEGGEPVVWLDGLDIPMLRFFGATFAENHDEPVQPLRRGEGDSLARYGSNMLPLRHQPTTPTSPLFSYPYARSREALERLARLERPDPWEGHKLRYVNPATGGWAMPTIATCLQLLPAGFLGQPARSTDASVYSVVEGSGVAQIGGRRFAFEAKDLFVVPSWAELRLEAGATDCVLFSFSDRPVQQALGILRESRETLAH
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
2- GO:0047922 Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+.
- GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 244 | 342 | CDD | cd06992 | cupin_GDO-like_C |
| 69 | 180 | CDD | cd02216 | cupin_GDO-like_N |
| 5 | 352 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls |
| 5 | 352 | InterPro | IPR014710 | RmlC-like jelly roll fold |
| 6 | 347 | SUPERFAMILY | SSF51182 | RmlC-like cupins |
| 6 | 347 | InterPro | IPR011051 | RmlC-like cupin domain superfamily |
| 93 | 164 | Pfam | PF07883 | Cupin domain |
| 93 | 164 | InterPro | IPR013096 | Cupin 2, conserved barrel |
| 3 | 350 | PANTHER | PTHR41517 | 1,2-DIOXYGENASE PROTEIN-RELATED |
| 3 | 350 | InterPro | IPR047183 | Gentisate 1,2-dioxygenase-like |
| 9 | 348 | NCBIfam | TIGR02272 | gentisate 1,2-dioxygenase |
| 9 | 348 | InterPro | IPR011960 | Gentisate 1,2 dioxygenase 1 |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA2470
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.736 | ||||||
| 6 | 0.729 | ||||||
| 7 | 0.267 | ||||||
| 2 | 0.245 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| 1HN | Q67FT0 | 188.2 Da LogP 2.24 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
c1ccc2c(c1)ccc(c2O)C(=O)O
|
|
| GTQ | Q67FT0 | 154.1 Da LogP 0.80 TPSA 77.8 | ✓ Ro5 | ✓ Clean |
c1cc(c(cc1O)C(=O)O)O
|
|
| SAL | Q67FT0 | 138.1 Da LogP 1.09 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
c1ccc(c(c1)C(=O)O)O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC406170 | 0.767 | 292.3 Da LogP 3.47 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1C(=O)c1ccc2ccccc2c1O
|
| ZINC1670022 | 0.679 | 258.2 Da LogP 2.03 TPSA 94.8 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1C(=O)c1cc(O)ccc1O
|
| ZINC19436641 | 0.667 | 203.2 Da LogP 1.66 TPSA 69.6 | ✓ Ro5 | ✓ Clean |
O=C(NO)c1ccc2ccccc2c1O
|
| ZINC34572642 | 0.667 | 274.2 Da LogP 2.16 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(-c2ccc(O)c(C(=O)O)c2)ccc1O
|
| ZINC100476725 | 0.656 | 290.3 Da LogP 4.00 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(CC(=O)c1ccc2ccccc2c1O)c1ccccc1
|
| ZINC71392 | 0.656 | 263.3 Da LogP 3.80 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
O=C(Nc1ccccc1)c1ccc2ccccc2c1O
|
| ZINC156804 | 0.655 | 251.1 Da LogP 3.30 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1Br
|
| ZINC1571200 | 0.655 | 216.2 Da LogP 2.24 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1C(=O)O
|
| ZINC400143 | 0.652 | 214.2 Da LogP 2.76 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1-c1ccccc1O
|
| ZINC38392758 | 0.650 | 242.2 Da LogP 2.16 TPSA 74.6 | ✓ Ro5 | Alert |
O=C(C(=O)c1ccccc1O)c1ccccc1O
|
| ZINC404363 | 0.650 | 214.2 Da LogP 2.33 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(c1ccccc1O)c1ccccc1O
|
| ZINC1667321 | 0.645 | 200.2 Da LogP 3.14 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CCC(=O)c1ccc2ccccc2c1O
|
| ZINC19837284 | 0.645 | 201.2 Da LogP 1.90 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CNC(=O)c1ccc2ccccc2c1O
|
| ZINC2048532872 | 0.640 | 350.3 Da LogP 3.83 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(-c2ccc(-c3ccc(O)c(C(=O)O)c3)cc2)ccc1O
|
| ZINC395504 | 0.636 | 264.3 Da LogP 3.76 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
O=C(Oc1ccccc1)c1ccc2ccccc2c1O
|
| ZINC114409961 | 0.633 | 204.2 Da LogP 2.83 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1S
|
| ZINC116843982 | 0.633 | 204.2 Da LogP 1.95 TPSA 77.8 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccc(O)cc2c1O
|
| ZINC1611750 | 0.633 | 204.2 Da LogP 1.95 TPSA 77.8 | ✓ Ro5 | Alert |
O=C(O)c1cc2ccccc2c(O)c1O
|
| ZINC71256811 | 0.633 | 298.1 Da LogP 3.14 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1I
|
| ZINC1661220 | 0.625 | 214.3 Da LogP 3.53 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CCCC(=O)c1ccc2ccccc2c1O
|
| ZINC1667322 | 0.625 | 214.3 Da LogP 3.38 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CC(C)C(=O)c1ccc2ccccc2c1O
|
| ZINC402129 | 0.625 | 202.2 Da LogP 2.33 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
COC(=O)c1ccc2ccccc2c1O
|
| ZINC105146 | 0.619 | 242.2 Da LogP 2.75 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1-c1ccccc1C(=O)O
|
| ZINC11757507 | 0.618 | 239.2 Da LogP 2.79 TPSA 70.4 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cnc2c(ccc3ccccc32)c1O
|
| ZINC154623 | 0.615 | 217.0 Da LogP 1.85 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(Br)ccc1O
|
| ZINC156387 | 0.615 | 264.0 Da LogP 1.70 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(I)ccc1O
|
| ZINC1701223 | 0.615 | 302.2 Da LogP 1.73 TPSA 132.1 | ✓ Ro5 | ✓ Clean |
O=C(c1ccc(O)c(C(=O)O)c1)c1ccc(O)c(C(=O)O)c1
|
| ZINC1701228 | 0.615 | 248.2 Da LogP 1.65 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2c(O)c(C(=O)O)ccc2c1O
|
| ZINC39190705 | 0.615 | 217.0 Da LogP 1.85 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(O)ccc1Br
|
| ZINC5511745 | 0.615 | 264.0 Da LogP 1.70 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(O)ccc1I
|
| ZINC39377800 | 0.613 | 248.3 Da LogP 4.21 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1-c1ccccc1
|
| ZINC6091797 | 0.613 | 204.2 Da LogP 1.95 TPSA 77.8 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2cc(O)ccc2c1O
|
| ZINC1727155 | 0.611 | 307.3 Da LogP 3.50 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc(NC(=O)c2ccc3ccccc3c2O)cc1
|
| ZINC4289585 | 0.609 | 226.1 Da LogP 0.49 TPSA 132.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(C(=O)O)c(C(=O)O)cc1O
|
| ZINC156898 | 0.607 | 204.2 Da LogP 1.95 TPSA 77.8 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc2cc(O)ccc2cc1O
|
| ZINC389193 | 0.607 | 214.2 Da LogP 2.33 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(c1ccccc1)c1cc(O)ccc1O
|
| ZINC1601721 | 0.600 | 255.3 Da LogP 3.17 TPSA 40.5 | ✓ Ro5 | ✓ Clean |
O=C(c1ccc2ccccc2c1O)N1CCCCC1
|
| ZINC1666270 | 0.600 | 264.3 Da LogP 2.72 TPSA 41.2 | ✓ Ro5 | ✓ Clean |
O=C(C[n+]1ccccc1)c1ccc2ccccc2c1O
|
| ZINC2296667055 | 0.600 | 274.3 Da LogP 4.44 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(C=Cc1ccccc1)c1ccc2ccccc2c1O
|
| ZINC24863672 | 0.600 | 202.2 Da LogP 2.17 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
O=C(O)Cc1ccc2ccccc2c1O
|
| ZINC4836747 | 0.600 | 274.3 Da LogP 4.44 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(/C=C/c1ccccc1)c1ccc2ccccc2c1O
|
| ZINC1634269 | 0.594 | 266.3 Da LogP 3.39 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccc3ccccc3c2c1C(=O)O
|
| ZINC1634583 | 0.594 | 272.3 Da LogP 2.67 TPSA 98.0 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(/C=C/c2cc(O)ccc2O)ccc1O
|
| ZINC1634585 | 0.594 | 274.3 Da LogP 2.29 TPSA 98.0 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(CCc2cc(O)ccc2O)ccc1O
|
| ZINC17220120 | 0.594 | 272.3 Da LogP 2.67 TPSA 98.0 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(/C=C\c2cc(O)ccc2O)ccc1O
|
| ZINC403483 | 0.594 | 202.2 Da LogP 2.55 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
COc1c(C(=O)O)ccc2ccccc12
|
| ZINC64219841 | 0.594 | 202.2 Da LogP 2.55 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
Cc1ccc2ccc(C(=O)O)c(O)c2c1
|
| ZINC2062 | 0.593 | 258.2 Da LogP 2.31 TPSA 83.8 | ✓ Ro5 | ✓ Clean |
O=C(Oc1ccccc1C(=O)O)c1ccccc1O
|
| ZINC3589671 | 0.593 | 288.3 Da LogP 2.09 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(Cc2ccc(O)c(C(=O)O)c2)ccc1O
|
| ZINC4760059 | 0.593 | 306.3 Da LogP 2.65 TPSA 115.1 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cc(Sc2ccc(O)c(C(=O)O)c2)ccc1O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.