Protein profile

PA2471

hypothetical protein

Genome: NC_002516.2

Gene: PA2471 Structure source: Experimental + AlphaFold UniProt Q9I111
Export view
Amino acids 232
Annotations 3
Features 8
PDB binders 3
Druggability 0.322

Overview

Basic information about this protein and its source genome.

Accession
PA2471
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2471
Status
annotated
Amino acids
232
Structure source
Experimental + AlphaFold
GO
GO:0018773 Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872 Binding to a metal ion. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.198
Human E-value
3.5000000000000004e-43
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.322
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0018773 Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate.
  • GO:0046872 Binding to a metal ion.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 232 FunFam G3DSA:3.90.850.10:FF:000005 FAA hydrolase family protein
26 231 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family
26 231 InterPro IPR011234 Fumarylacetoacetase-like, C-terminal
21 232 SUPERFAMILY SSF56529 FAH
21 232 InterPro IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily
1 232 Gene3D G3DSA:3.90.850.10 -
1 232 InterPro IPR036663 Fumarylacetoacetase-like, C-terminal domain superfamily
20 231 PANTHER PTHR11820 ACYLPYRUVASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6J5Y
X-ray 1.98 Å A
99.6% 2-232
PDBe RCSB PDBj File
Viewing
AlphaFold PA2471
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.322
5 0.271
2 0.266

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.65 0.404

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

18 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
PYR
6J5Y 1.98 Å Open crystal
88.1 Da LogP -0.34 TPSA 54.4 ✓ Ro5 ✓ Clean CC(=O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.