Protein profile

PA2476

thiol:disulfide interchange protein DsbG

Genome: NC_002516.2

Gene: dsbG PA2476 Structure source: AlphaFold UniProt Q9I106
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Amino acids 256
Annotations 3
Features 19
PDB binders 0
Druggability 0.873

Overview

Basic information about this protein and its source genome.

Accession
PA2476
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
dsbG PA2476
Status
annotated
Amino acids
256
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003756 Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.873
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0003756 Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
123 253 Pfam PF13098 Thioredoxin-like domain
123 253 InterPro IPR012336 Thioredoxin-like fold
25 256 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 86 SUPERFAMILY SSF54423 DsbC/DsbG N-terminal domain-like
27 86 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
112 255 Gene3D G3DSA:3.40.30.10 Glutaredoxin
96 253 SUPERFAMILY SSF52833 Thioredoxin-like
96 253 InterPro IPR036249 Thioredoxin-like superfamily
40 253 CDD cd03020 DsbA_DsbC_DsbG
40 253 InterPro IPR033954 Disulphide bond isomerase, DsbC/G
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
28 96 Gene3D G3DSA:3.10.450.70 -
28 96 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
10 255 PANTHER PTHR35272 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2476
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.873
1 0.625
4 0.457