Protein profile

PA2482

cytochrome C

Genome: NC_002516.2

Gene: PA2482 Structure source: AlphaFold UniProt Q9I100
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Amino acids 217
Annotations 5
Features 26
PDB binders 0
Druggability 0.83

Overview

Basic information about this protein and its source genome.

Accession
PA2482
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2482
Status
annotated
Amino acids
217
Structure source
AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506 Binding to an iron (Fe) ion. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.83
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
22 217 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
128 211 ProSiteProfiles PS51007 Cytochrome c family profile.
128 211 InterPro IPR009056 Cytochrome c-like domain
141 210 Pfam PF00034 Cytochrome c
141 210 InterPro IPR009056 Cytochrome c-like domain
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
7 210 PANTHER PTHR33751 CBB3-TYPE CYTOCHROME C OXIDASE SUBUNIT FIXP
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
21 103 SUPERFAMILY SSF46626 Cytochrome c
21 103 InterPro IPR036909 Cytochrome c-like domain superfamily
31 102 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
31 102 InterPro IPR009056 Cytochrome c-like domain
1 212 PIRSF PIRSF000005 Cytochrome_c4
1 212 InterPro IPR024167 Cytochrome c4-like
18 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 107 Gene3D G3DSA:1.10.760.10 -
22 107 InterPro IPR036909 Cytochrome c-like domain superfamily
120 210 Gene3D G3DSA:1.10.760.10 -
120 210 InterPro IPR036909 Cytochrome c-like domain superfamily
125 210 SUPERFAMILY SSF46626 Cytochrome c
125 210 InterPro IPR036909 Cytochrome c-like domain superfamily
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
20 109 ProSiteProfiles PS51007 Cytochrome c family profile.
20 109 InterPro IPR009056 Cytochrome c-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2482
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.83
2 0.697