Protein profile

PA2488

transcriptional regulator

Genome: NC_002516.2

Gene: PA2488 Structure source: AlphaFold UniProt Q9I0Z4
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Amino acids 254
Annotations 5
Features 24
PDB binders 0
Druggability 0.896

Overview

Basic information about this protein and its source genome.

Accession
PA2488
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2488
Status
annotated
Amino acids
254
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.896
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
145 249 FunFam G3DSA:1.10.10.60:FF:000132 AraC family transcriptional regulator
18 79 Pfam PF02311 AraC-like ligand binding domain
18 79 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
230 246 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
230 246 InterPro IPR020449 Transcription regulator HTH, AraC- type
215 230 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
215 230 InterPro IPR020449 Transcription regulator HTH, AraC- type
16 87 Gene3D G3DSA:2.60.120.10 Jelly Rolls
16 87 InterPro IPR014710 RmlC-like jelly roll fold
20 212 SUPERFAMILY SSF51182 RmlC-like cupins
20 212 InterPro IPR011051 RmlC-like cupin domain superfamily
10 101 CDD cd06124 cupin_NimR-like_N
146 251 Gene3D G3DSA:1.10.10.60 -
164 246 SMART SM00342 aracneu4
164 246 InterPro IPR018060 DNA binding HTH domain, AraC-type
170 246 Pfam PF12833 Helix-turn-helix domain
170 246 InterPro IPR018060 DNA binding HTH domain, AraC-type
3 250 PANTHER PTHR11019 HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
198 242 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
198 242 InterPro IPR018062 HTH domain AraC-type, conserved site
151 248 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
151 248 InterPro IPR018060 DNA binding HTH domain, AraC-type
201 247 SUPERFAMILY SSF46689 Homeodomain-like
201 247 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2488
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.896
5 0.816