Protein profile

PA2493

resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE

Genome: NC_002516.2

Gene: PA2493 mexE Structure source: AlphaFold UniProt Q9I0Y9
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Amino acids 414
Annotations 5
Features 21
PDB binders 0
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
PA2493
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2493 mexE
Status
annotated
Amino acids
414
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
98 171 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
387 414 MobiDBLite mobidb-lite consensus disorder prediction
281 372 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
281 372 Gene3D G3DSA:2.40.420.20 -
25 42 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 381 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
104 124 Coils Coil Coil
57 280 Gene3D G3DSA:2.40.30.170 -
149 169 Coils Coil Coil
53 294 SUPERFAMILY SSF111369 HlyD-like secretion proteins
65 290 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
65 290 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
204 280 FunFam G3DSA:2.40.30.170:FF:000011 Efflux RND transporter periplasmic adaptor subunit
39 371 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
39 371 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
1 42 Phobius SIGNAL_PEPTIDE Signal peptide region
43 414 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
63 206 Gene3D G3DSA:2.40.50.100 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2493
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.843
2 0.218