Protein profile

PA2513

anthranilate dioxygenase small subunit

Genome: NC_002516.2

Gene: PA2513 antB Structure source: AlphaFold UniProt Q9I0W9
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Amino acids 163
Annotations 4
Features 11
PDB binders 0
Druggability 0.902

Overview

Basic information about this protein and its source genome.

Accession
PA2513
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2513 antB
Status
annotated
Amino acids
163
Structure source
AlphaFold
GO
GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.902
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
  • GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.
  • GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
  • GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
5 162 CDD cd00667 ring_hydroxylating_dioxygenases_beta
5 162 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
5 163 Gene3D G3DSA:3.10.450.50 -
3 161 PANTHER PTHR41534 BLR3401 PROTEIN
3 161 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
15 155 Pfam PF00866 Ring hydroxylating beta subunit
15 155 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
9 163 NCBIfam TIGR03231 anthranilate 1,2-dioxygenase small subunit
9 163 InterPro IPR017640 Anthranilate 1,2-dioxygenase, small subunit
1 163 SUPERFAMILY SSF54427 NTF2-like
1 163 InterPro IPR032710 NTF2-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2513
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.485
2 0.309
6 0.217