Protein profile

PA2517

toluate 1,2-dioxygenase subunit beta

Genome: NC_002516.2

Gene: PA2517 xylY Structure source: AlphaFold UniProt Q9I0W5
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Amino acids 162
Annotations 3
Features 11
PDB binders 0
Druggability 0.554

Overview

Basic information about this protein and its source genome.

Accession
PA2517
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2517 xylY
Status
annotated
Amino acids
162
Structure source
AlphaFold
GO
GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.554
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
  • GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.
  • GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
4 160 PANTHER PTHR41534 BLR3401 PROTEIN
4 160 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
14 154 Pfam PF00866 Ring hydroxylating beta subunit
14 154 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
9 162 NCBIfam TIGR03232 benzoate 1,2-dioxygenase small subunit
9 162 InterPro IPR017641 Benzoate 1,2-dioxygenase, small subunit
5 161 CDD cd00667 ring_hydroxylating_dioxygenases_beta
5 161 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
2 162 Gene3D G3DSA:3.10.450.50 -
5 161 SUPERFAMILY SSF54427 NTF2-like
5 161 InterPro IPR032710 NTF2-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2517
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.554