Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2528
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2528
Status: annotated
Amino acids: 426
Structure source: AlphaFold

GO

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
64	392	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
64	392	InterPro	IPR006143	RND efflux pump, membrane fusion protein
78	315	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
129	156	Coils	Coil	Coil
302	393	FunFam	G3DSA:2.40.420.20:FF:000001	Efflux RND transporter periplasmic adaptor subunit
388	426	MobiDBLite	mobidb-lite	consensus disorder prediction
36	426	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
228	301	FunFam	G3DSA:2.40.30.170:FF:000006	Multidrug resistance protein MdtA
1	15	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
82	301	Gene3D	G3DSA:2.40.30.170	-
409	426	MobiDBLite	mobidb-lite	consensus disorder prediction
1	39	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
302	393	Gene3D	G3DSA:2.40.420.20	-
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
88	232	Gene3D	G3DSA:2.40.50.100	-
123	196	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
12	396	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
16	35	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
87	311	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
87	311	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2528	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.753
3				0.333

PA2528