Protein profile

PA2531

aminotransferase

Genome: NC_002516.2

Gene: GUL26_10575 PA2531 Structure source: AlphaFold UniProt Q9I0V2 UniProt G3XCK5
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Amino acids 374
Annotations 4
Features 19
PDB binders 5
Druggability 0.642

Overview

Basic information about this protein and its source genome.

Accession
PA2531
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
GUL26_10575 PA2531
Status
annotated
Amino acids
374
Structure source
AlphaFold
GO
GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009058 A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.642
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPALSRRSFVTLTALASSSILLSPRAFAGSGATSAAGKPQETFLDFNESPYGPSAKARAAMQRAAALCGRYDYDAQDALVGLFAKQNGIPAECVHAYCGSRQPLQYAVAAFTGKERGLVIADPSYDSVVGAAQAQGAKVAAVPLDAEAAHDIERMLAAAQRDAGLIYICNPNNPTGTLTPHERIVRAIERKPERSVVLVDEAYIHFSDAPSVVGLAVQRQDVLVLRTFSKLYGMAGARLGLAIGHPQLLARLERFGGHNVVPSPTAHAGLESLRDDDLVPRRKQQNAEVRERTIAWLRQQGFRCTASQSNCFMVDMRRPAELVIAELEKQRVHVGRPWASWPNWVRVTVGSEEEMQAFRSAFASVSRRHQVAMR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
  • GO:0008483 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0009058 A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
40 358 Gene3D G3DSA:3.90.1150.10 Aspartate Aminotransferase, domain 1
40 358 InterPro IPR015422 Pyridoxal phosphate-dependent transferase, small domain
60 358 Pfam PF00155 Aminotransferase class I and II
60 358 InterPro IPR004839 Aminotransferase, class I/classII
1 28 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
23 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
40 365 PANTHER PTHR43643 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE 2
44 363 CDD cd00609 AAT_like
53 275 Gene3D G3DSA:3.40.640.10 -
53 275 InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major domain
1 28 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 28 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
42 363 SUPERFAMILY SSF53383 PLP-dependent transferases
42 363 InterPro IPR015424 Pyridoxal phosphate-dependent transferase
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
10 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 374 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2531
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.642

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
144
3CQ5
Q9KJU4 122.1 Da LogP -1.72 TPSA 60.7 ✓ Ro5 ✓ Clean C[N+](CO)(CO)CO
HSA
1FG3
P06986 221.2 Da LogP -0.61 TPSA 121.5 ✓ Ro5 ✓ Clean c1c(nc[nH]1)CC(COP(=O)(O)O)N
PE4
4WBT
Q92R63 354.4 Da LogP 0.11 TPSA 84.8 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCOCCO
PMP
1FG7
P06986 248.2 Da LogP 0.16 TPSA 125.9 ✓ Ro5 ✓ Clean Cc1c(c(c(cn1)COP(=O)(O)O)CN)O
SIN
4R5Z
P9WML5 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.