Protein profile

PA2533

sodium:alanine symporter

Genome: NC_002516.2

Gene: PA2533 Structure source: AlphaFold UniProt Q9I0V1
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Amino acids 449
Annotations 5
Features 53
PDB binders 0
Druggability 0.825

Overview

Basic information about this protein and its source genome.

Accession
PA2533
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2533
Status
annotated
Amino acids
449
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.825
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005283 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

53 records
Show feature table
Start End DB Term Name
419 439 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
168 186 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
417 439 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 213 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
61 449 FunFam G3DSA:1.20.1740.10:FF:000004 Sodium:alanine symporter family protein
234 244 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 167 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
245 268 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
310 331 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
393 413 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 449 Gene3D G3DSA:1.20.1740.10 Amino acid/polyamine transporter I
374 392 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
303 325 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
440 449 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
250 272 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
269 309 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 448 Pfam PF01235 Sodium:alanine symporter family
56 448 InterPro IPR001463 Sodium:alanine symporter
15 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 115 PRINTS PR00175 Sodium/alanine symporter signature
93 115 InterPro IPR001463 Sodium:alanine symporter
214 233 PRINTS PR00175 Sodium/alanine symporter signature
214 233 InterPro IPR001463 Sodium:alanine symporter
186 204 PRINTS PR00175 Sodium/alanine symporter signature
186 204 InterPro IPR001463 Sodium:alanine symporter
353 375 PRINTS PR00175 Sodium/alanine symporter signature
353 375 InterPro IPR001463 Sodium:alanine symporter
412 432 PRINTS PR00175 Sodium/alanine symporter signature
412 432 InterPro IPR001463 Sodium:alanine symporter
309 327 PRINTS PR00175 Sodium/alanine symporter signature
309 327 InterPro IPR001463 Sodium:alanine symporter
99 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
414 418 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
80 102 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
187 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 448 PANTHER PTHR30330 AGSS FAMILY TRANSPORTER, SODIUM-ALANINE
4 448 InterPro IPR001463 Sodium:alanine symporter
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
388 407 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16 443 NCBIfam TIGR00835 amino acid carrier protein
16 443 InterPro IPR001463 Sodium:alanine symporter
213 235 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
94 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
214 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
69 93 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
351 373 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 14 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
332 350 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2533
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.825
5 0.526
11 0.455
7 0.433