Protein profile

PA2539

hypothetical protein

Genome: NC_002516.2

Gene: PA2539 Structure source: AlphaFold UniProt Q9I0U5
Export view
Amino acids 437
Annotations 5
Features 43
PDB binders 1
Druggability 0.963

Overview

Basic information about this protein and its source genome.

Accession
PA2539
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2539
Status
annotated
Amino acids
437
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016311 The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0008138 Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. GO:0006470 The process of removing one or more phosphoric residues from a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.159
Human E-value
3.64e-07
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.963
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016311 The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
  • GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
  • GO:0008138 Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
  • GO:0006470 The process of removing one or more phosphoric residues from a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

43 records
Show feature table
Start End DB Term Name
35 186 CDD cd03386 PAP2_Aur1_like
74 92 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
148 165 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
141 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
285 437 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
255 265 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
236 254 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
284 417 SUPERFAMILY SSF52799 (Phosphotyrosine protein) phosphatases II
284 417 InterPro IPR029021 Protein-tyrosine phosphatase-like
169 186 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
63 73 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
19 41 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
231 235 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
74 96 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 121 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
58 431 PANTHER PTHR47216 -
171 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
266 284 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 420 Gene3D G3DSA:3.90.190.10 Protein tyrosine phosphatase superfamily
279 420 InterPro IPR029021 Protein-tyrosine phosphatase-like
290 423 SMART SM00195 dsp_5
290 423 InterPro IPR020422 Dual specificity protein phosphatase domain
347 418 Pfam PF00782 Dual specificity phosphatase, catalytic domain
347 418 InterPro IPR000340 Dual specificity phosphatase, catalytic domain
122 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
208 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 226 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
147 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
189 207 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
350 415 ProSiteProfiles PS50056 Tyrosine specific protein phosphatases domain profile.
350 415 InterPro IPR000387 Tyrosine-specific protein phosphatases domain
230 252 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
42 62 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 18 SignalP_EUK SignalP-TM SignalP-TM
166 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
287 422 CDD cd14527 DSP_bac

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2539
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.963
9 0.559

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

136 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
STT
3F81
P51452 581.7 Da LogP 5.56 TPSA 101.7 2 viol. Alert c1ccc(cc1)n2cc(c(n2)c3ccc(cc3)Oc4ccccc4F)/C=C/5…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.